The Institute scientist, Brian Virgil, is the first to successfully create a serum that recreated his original human DNA while overwriting the FEV present in his system. While a cure for the effects of FEV was speculated by ZAX 1.2, this is the only strain that can be cured. They are commonly accompanied by other FEV creations, such as mutant hounds and unstable early experiments, the behemoths.

Interestingly, the Institute's creations consider themselves both to be superior to humans and their victims, seeing violence as a form of retribution.

They are somewhat intelligent, forming unique tribes and representing a variety of mostly hostile attitudes.ДЄ super mutant companion, Strong, appears, alongside a handful of peaceful super mutants, providing insight into the communal society of the mutants. These mutants are the byproduct of its research into generation 3 synths, dumped into the Commonwealth. Centaurs are common companions of the super mutants, another hideous effect of EEP mutation.ДЇallout 4 features super mutants created by the Institute using an FEV sample acquired through clandestine means. Uniquely, these super mutants never seem to stop growing and ancient, gigantic mutants called behemoths can be encountered. These represent the only non-hostile interactions with them in the entire game. Only two non-hostile super mutants appear in the game, Fawkes, a late game companion who also prefers to be called a meta-human rather a super mutant, and Uncle Leo, a randomly encountered traveler. They act as hostile creatures barely capable of speech or coherent social organization, but are considered a major threat by the Lyons' Brotherhood of Steel, which has engaged them in a war of attrition for nearly two decades by the time the game starts. These mutants are almost invariably hostile, borderline feral, and completely asexual. Fallout 3 features super mutants derived from the Evolutionary Experimentation Program (EEP), an FEV derivative used at Vault 87.

Fallout 4 super mutant companion mod